Research Articles (University of Pretoria)

Permanent URI for this collectionhttp://hdl.handle.net/2263/121

This collection offers open access to the full text of research articles published by staff, students and affiliates of the University of Pretoria. These items are identical in content to their published counterparts. It is linked to the Research Information System and complements the Annual Research Report.

Access to the full text of UP theses and dissertations is available at UP Electronic Theses and Dissertations.

Information and guidelines for authors/ submitters available at http://www.ais.up.ac.za/openup/index.htm.

For inquiries regarding this collection or items in the collection, please contact : Hendriette Jansen van Vuuren
Tel.: +27 12 420 4712

Browse

Now showing 1 - 20 of 39639

Plasmids encode and can mobilize onion pathogenicity in Pantoea agglomerans
(Oxford University Press, 2025-03) Shin, Gi Yoon; Asselin, Jo Ann; Smith, Amy; Aegerter, Brenna; Coutinho, Teresa A.; Zhao, Mei; Dutta, Bhabesh; Mazzone, Jennie; Neupane, Ram; Gugino, Beth; Hoepting, Christy; Khanal, Manzeal; Malla, Subas; Nischwitz, Claudia; Sidhu, Jaspreet; Burke, Antoinette Machado; Davey, Jane; Uchanski, Mark; Derie, Michael L.; Du Toit, Lindsey J.; Stresow-Cortez, Stephen; Bonasera, Jean M.; Stodghill, Paul; Kvitko, Brian
Pantoea agglomerans is one of four Pantoea species reported in the USA to cause bacterial rot of onion bulbs. However, not all P. agglomerans strains are pathogenic to onion. We characterized onion-associated strains of P. agglomerans to elucidate the genetic and genomic signatures of onion-pathogenic P. agglomerans. We collected >300 P. agglomerans strains associated with symptomatic onion plants and bulbs from public culture collections, research laboratories, and a multi-year survey in 11 states in the USA. Combining the 87 genome assemblies with 100 high-quality, public P. agglomerans genome assemblies we identified two well-supported P. agglomerans phylogroups. Strains causing severe symptoms on onion were only identified in Phylogroup II and encoded the HiVir pantaphos biosynthetic cluster, supporting the role of HiVir as a pathogenicity factor. The P. agglomerans HiVir cluster was encoded in two distinct plasmid contexts: (i) as an accessory gene cluster on a conserved P. agglomerans plasmid (pAggl), or (ii) on a mosaic cluster of plasmids common among onion strains (pOnion). Analysis of closed genomes revealed that the pOnion plasmids harbored alt genes conferring tolerance to Allium thiosulfinate defensive chemistry and many harbored cop genes conferring resistance to copper. We demonstrated that the pOnion plasmid pCB1C can act as a natively mobilizable pathogenicity plasmid that transforms P. agglomerans Phylogroup I strains, including environmental strains, into virulent pathogens of onion. This work indicates a central role for plasmids and plasmid ecology in mediating P. agglomerans interactions with onion plants, with potential implications for onion bacterial disease management.
Building IPECP into community health promotion
(Health and Medical Publishing Group, 2024-07-01) Abdoola, Shabnam Salim; Milton, Carmen; shabnam.abdoola@up.ac.za
Due to its culturally and linguistically diverse society, high prevalence of communication disorders, resource limitations, and fragmented healthcare services, South Africa (SA) needs to integrate interprofessional education and collaborative practice (IPECP) into community health promotion. IPECP in health professions education is necessary in preparing ‘collaborative practice-ready’ health care professionals who are socially accountable and prepared to respond to local health needs. Integrating IPECP strategies into existing curricula and placing interprofessional students at the same clinical sites can promote collaborative education and practice. Providing students with interprofessional clinical practice experience provides real world experience and insight, while enhancing an understanding and respect for other professionals.
Self-growth suppression in Bradyrhizobium diazoefficiens is caused by a diffusible antagonist
(Oxford University Press, 2025-03) Sandhu, Armaan Kaur; Fischer, Brady R.; Subramanian, Senthil; Hoppe, Adam D.; Brözel, Volker Siegfried
Microbes in soil navigate interactions by recognizing kin, forming social groups, exhibiting antagonistic behavior, and engaging in competitive kin rivalry. Here, we investigated a novel phenomenon of self-growth suppression (sibling rivalry) observed in Bradyrhizobium diazoefficiens USDA 110. Swimming colonies of USDA 110 developed a distinct demarcation line and inter-colony zone when inoculated adjacent to each other. In addition to self, USDA 110 suppressed growth of other Bradyrhizobium strains and several other soil bacteria. We demonstrated that the phenomenon of sibling rivalry is due to growth suppression but not cell death. The cells in the inter-colony zone were culturable but had reduced respiratory activity, ATP levels, and motility. The observed growth suppression was due to the presence of a diffusible effector compound. This effector was labile, preventing extraction, and identification, but it is unlikely a protein or a strong acid or base. This counterintuitive phenomenon of self-growth suppression suggests a strategic adaptation for conserving energy and resources in competitive soil environments. Bradyrhizobium’s utilization of antagonism including self-growth suppression likely provides a competitive advantage for long-term success in soil ecosystems.
Bradyrhizobium diazoefficiens cultures display phenotypic heterogeneity
(Oxford University Press, 2025-03) Sarao, Sukhvir K.; Sandhu, Armaan K.; Hanson, Ryan L.; Govil, Tanvi; Brözel, Volker Siegfried
Bacteria growing in liquid culture are assumed to be homogenous in phenotype. Characterization of individual cells shows that some clonal cultures contain more than one phenotype. Bacteria appear to employ bet hedging where various phenotypes help the species survive in diverse niches in soil and rhizosphere environments. We asked whether the agriculturally significant bacterium Bradyrhizobium diazoefficiens USDA 110, which fixes nitrogen with soybean plants, displays phenotypic heterogeneity when grown under laboratory conditions. We observed differential binding of sugar-specific lectins in isogenic populations, revealing differential surface properties. We employed Percoll™ density gradient centrifugation to separate clonal populations of exponential and stationary phase B. diazoefficiens into four fractions and characterized their phenotype by proteomics. Specific phenotypes were then characterized in detail. Fractions varied by cell size, polyhydroxyalkanoate content, lectin binding profile, growth rate, cellular adenosine triphosphate, chemotaxis, and respiration activity. Phenotypes were not heritable because the specific buoyant densities of fractions equilibrated within 10 generations. We propose that heterogeneity helps slow growing B. diazoefficiens proliferate and maintain populations in the different environments in soil and the rhizosphere.
DPANN symbiont of Haloferax volcanii accelerates xylan degradation by the non-host haloarchaeon Halorhabdus sp.
(Elsevier, 2025-02-21) Reva, Oleg N.; La Cono, Violetta; Marturano, Laura; Crisafi, Francesca; Smedile, Francesco; Mudaliyar, Manasi; Ghosal, Debnath; Selivanova, Elena A.; Ignatenko, Marina E.; Ferrer, Manuel; Fernandez-Lopez, Laura; Krupovic, Mart; Yakimov, Michail M.; oleg.reva@up.ac.za
This study examines a natural consortium of halophilic archaea, comprising xylan-degrading Halorhabdus sp. SVX81, consortium cohabitant Haloferax volcanii SVX82 (formerly H. lucentense SVX82), and its DPANN ectosymbiont Ca. Nanohalococcus occultus SVXNc. Transcriptomics and targeted metabolomics demonstrated that the tripartite consortium outperformed individual and the Halorhabdus sp. SVX81 with H. volcanii SVX82 bipartite cultures in xylan degradation, exhibiting a division of labor: the DPANN symbiont processed glycolysis products, while other members performed xylan depolymerization and biosynthesis of essential compounds. Electron microscopy and cryo-electron tomography revealed the formation of heterocellular biofilms interlinked by DPANN cells. The findings demonstrated that DPANN symbionts can interact directly with other members of microbial communities, which are not their primary hosts, influencing their gene expression. However, DPANN proliferation requires their primary host presence. The study highlights the collective contribution of consortium members to xylan degradation and their potential for biotechnological applications in the management of hypersaline environments.
Segment reduction-based SVPWM applied three-level F-type inverter for power quality conditioning in an EV proliferated distributed system
(Wiley, 2025-02) Madhavan, Meenakshi; N., Chellammal; Bansal, Ramesh C.
The objective of this paper lies in the realization of a three-level F-type inverter (3L-FTI) as a shunt active filter in an EV-proliferated environment. The switches are triggered using segment reduced space vector pulse width modulation (SVPWM). This modulation technique provides a lower number of switching transitions than existing PWM strategies. Consequently, the inverter switches experience a decrease in both switching stress and switching losses. A 3L-FTI is a diode-free structure that reduces the harmonics in the source current with a high power factor (PF), where instantaneous reactive power (IRPT) theory is employed to generate the reference currents from the utility grid. In contrast to traditional three-level inverters, two-thirds of switches in 3L-FTI can tolerate a voltage stress equal to half of the DC input voltage. While studying the behaviour of this shunt active filter, with three different nonlinear loading conditions, the current total harmonic distortion (THD) is reduced from 28.43% to 2.13% after compensation, which is under 5% of IEEE standard 519-2014. Therefore, the 3L-FTI controlled by segment reduction SVPWM can be considered as better candidate for active filter in an EV proliferated distribution system.
Moral disengagement and charitable giving : experimental evidence from South Africa
(Wiley, 2025) Chingwere, Fadzay; Nicholls, Nicky; Yitbarek, Eleni; nicky.nicholls@up.ac.za
Moral disengagement has been linked to harmful behaviour and reduced inclination to assist others. Charitable giving, a form of assistance to others, is an important form of domestic resource mobilization in middle-income countries. Moral disengagement can impact decisions regarding charitable giving by enabling individuals to rationalize less generous behaviour. We conducted a survey to investigate how moral disengagement varies across demographic groups and whether moral disengagement helps explain charitable giving. Because studies have shown that interventions can reduce moral disengagement, research highlighting groups demonstrating more moral disengagement can help to target such interventions. Understanding factors associated with moral disengagement can also show whether such interventions might be worthy of investment. We find higher moral disengagement for men and younger and less educated and unemployed respondents. Moral disengagement was a significant predictor of self-reported less frequent charitable giving but not of the amount donated in an incentivised giving task.
The entrepreneurial leap : social capital's role in moving beyond side-hustle entrepreneurship in South Africa
(Wiley, 2025) Chetty, Sanusha; Fourie, Alicia; FourieA@gibs.co.za
Entrepreneurship is broadly recognised as a driver of innovation and entrepreneurial success. Within the entrepreneurial landscape, many individuals initially embark on their journey as ‘side-hustle’ entrepreneurs, engaging in small, part-time ventures. Eventually, some of these entrepreneurs make the leap to full-time entrepreneurs. However, the specific factors that facilitate this critical transition are not fully understood. This study investigates the role social capital plays in facilitating the transition from side-hustle entrepreneurship to full-time entrepreneurship in South Africa. The study adopts an inductive research approach and employs a qualitative exploratory methodology, collecting data from semi-structured interviews with side-hustle entrepreneurs who have either transitioned to full-time entrepreneurship or are considering doing so. The findings reveal that mentorship and trusted networks are pivotal in providing the necessary support, resources and opportunities for transitioning to full-time entrepreneurship. By delving into the dynamics of social capital in an entrepreneurship context, the study can potentially inform South African policies on entrepreneurship promotion, education and development, helping to stimulate much-needed economic growth in South Africa.
Perspective on metal-organic frameworks-based atmospheric water harvesting systems towards universal adoption
(Elsevier, 2025-08) Manyimo, Tonderai Leeroy; Ren, Jianwei; Wang, Hui; Peng, Shengjie; jianwei.ren@up.ac.za
Climate change and the unequal distribution of freshwater resources are contributing factors to the global water crisis. Metal-organic frameworks (MOFs) have become a viable material for atmospheric water harvesting (AWH) due to their function in low relative humidity (RH) conditions. Their potential in dry conditions is demonstrated by MOF-801's up to 0.3 L/kg MOF/day and MOF-303's 0.7–1 liter/kg MOF/day. MOFs' high porosity, adjustable adsorption characteristics, and reduced regeneration temperatures have made them stand out as better alternatives. In this review, MIL-101(Cr), MOF-801, and MOF-303 are recommended as appropriate for AWH applications due to their promising water adsorption capabilities. Studies have shown that MIL-101(Cr) can outperform conventional desiccants with a water uptake of up to 1.5 g/g. It is also discussed that MOFs are successful in arid areas where traditional methods are ineffective due to their exceptional selectivity for water adsorption, even in low-humidity conditions. In order to evaluate the most recent developments in MOF-based AWH technologies, this review compared their performance to that of current AWH techniques. Although the production of MOFs is still expensive, economic feasibility studies show that improvements in scalable synthesis techniques, such as green solvent-assisted fabrication, could drastically lower manufacturing costs. With current research concentrating on enhancing material stability to extend operational lifespans, MOFs' long-term viability is also greatly influenced by their durability and recyclability. Furthermore, total efficiency may be increased by hybrid AWH systems that combine MOFs with other adsorption materials, such as hydrogels. In this review, recent developments in MOF-based AWH systems are studied, with an emphasis on material characteristics, system performance, and large-scale viability.
Conversion–lithiophilicity hosts toward long-term and high-energy-density lithium metal batteries
(Wiley, 2025) Huang, Aoming; Huang, Hongjiao; Li, Shaoxiong; Pan, Xiansong; Wang, Ai-Yin; Chen, Han-Yi; Wang, Tao; Li, Linlin; Maximov, Maxim; Ren, Jianwei; Wu, Yuping; Peng, Shengjie
Please read abstract in the article.
Shortening the reaction pathway of sulfur redox kinetics with 2,5-dichloro-1,4-benzoquinone to minimize the shuttle effect in lithium-sulfur batteries
(American Chemical Society, 2025-04) Shao, Jiayi; Wang, Hanxiao; Huang, Xinjie; Ma, Xianguo; Wang, Xuyun; Huang, Hongsheng; Ren, Jianwei; Wang, Rongfang; jianwei.ren@up.ac.za
Please read abstract in the article.
New friction factor correlation for phase-change flow in plate heat exchangers
(Taylor and Francis, 2025) Mukkamala, Yagnavalkya; Dirker, Jaco
This article reports a new two-phase friction factor correlation for condensing and evaporating flows in plate heat exchangers. Over a thousand condensation pressure drop data compiled from seventeen articles were reduced to a two-phase friction factor correlation and successfully evaluated with data not used for correlation development. Similarly, over two thousand evaporation pressure drop data were collected from twenty-four articles and were empirically modeled to yield a two-phase friction factor, which was also successfully validated with independent data. The condensation friction factor correlation fit 72% of the data within ±50% and modeled 92% of the evaluation data within ±50%. Similarly, the evaporation friction factor correlation fit 64.9% of the data within ±50 and 89.8% of the evaluation data within ±50%. Pressure drop in condensers was predominantly due to convective condensation and buoyancy forces. Inertial forces and convective boiling were mainly responsible for the pressure drop in evaporators. As the Weber number was much <1, drop condensation and nucleate boiling were insignificant. Meta-analysis strongly recommended deploying plate heat exchangers as condensers for lowering the pressure drop and was inconclusive for evaporators.
Pilot of methadone for recently incarcerated people with human immunodeficiency virus and opioid use in South Africa
(Mary Ann Liebert, 2025) Bhoora, Urvisha; An, Yangxi; Owczarzak, Jill; Ndini, Pretty; Moyo, Derrick; Shelly, Shaun; Marcus, Tessa S.; Steiner, Laura; Corcoran, Peter C.; Pollock, Sarah; Lefoka, Moganki H.; Mabuto, Tonderai; Hugo, J.F.M. (Jannie); Hoffmann, Christopher J.
In South Africa, there is no provision of medication for opioid use disorder (MOUD) for people who are incarcerated or were recently incarcerated. This study aimed to describe MOUD uptake and barriers among people living with human immunodeficiency virus and using illicit opioids reentering the community from incarceration. A mixed-method exploratory study was conducted between September 2021 and September 2022 in South Africa, during which we offered low-barrier MOUD and harm reduction services. We followed 23 participants postrelease and observed a low uptake of MOUD after release (8 of 23, 35%). Reported barriers to MOUD included perceived ineffectiveness, a preference for residential withdrawal management, and delays in initiating MOUD. Innovation is needed in strategies to deliver MOUD and harm reduction in South Africa.
Higher genotyping performance of the applied biosystems TaqPath Seq HIV-1 genotyping kit against ViroSeq HIV-1 genotyping Kit in HIV protease, reverse transcriptase, and integrase regions
(Dove Press, 2025-04) Choga, Ontlametse Thato; Okafor, Obiageli; Lemogang, Goitseone Martha; Choga, Wonderful Tatenda; Muzanywa, Gaonyadiwe; Garcia, Andrea E.; Moyo, Sikhulile; Gaseitsiwe, Simani
PURPOSE : We assessed the performance of Applied Biosystems TaqPath Seq HIV-1 Genotyping Kit (CE-IVD) (TaqPath Kit) against the ViroSeq HIV-1 Genotyping Assays in genotyping HIV protease (PR), reverse transcriptase (RT), and integrase (INI) regions. METHODS : The study included 43 HIV-1 plasma specimens: 20 from people living with HIV-1C and 23 well-characterized HIV-positive Virology Quality Assurance (VQA) samples with PR-, RT-, and INI mutations. VQA samples included HIV-1 subtypes A, B, C, D, F, G, CRFO2_AG and URF. HIV-1 RNA extracted from all specimens was tested with both genotyping assays. Known HIV drug resistance mutations (DRMs) were identified using the Stanford HIV drug resistance database. Sequencing success rates, nucleotide identity, and DRMs from the two commercial assays were compared. RESULTS : Of 43 samples, TaqPath Kit amplified 93.0% (40) for HIV PR/RT and 97.7% (42) for HIV INI regions, compared to ViroSeq Assays, which amplified 69.8% (30) and 72.1% (31) for PR/RT and INI, respectively. The TaqPath Kit successfully sequenced 90.0% (36/40) PR/RT and 97.6% (41/42) INI amplicons, while ViroSeq Assays sequenced 53.3% (16/30) PR/RT and 87.1% (27/31) INI amplicons. The mean nucleotide similarity was 98.8% (SD ± 1.30), 99.6% (SD ± 1.32) and 99.2% (SD ± 0.72) for paired RT, PR and INI sequences, respectively. The TaqPath Kit detected 97.2% (35/36) of DRMs identified by the ViroSeq Assays and an additional 83 mutations and polymorphisms in samples that failed genotyping with the ViroSeq Assays. Among these, 85.5% (71/83) were confirmed by the reference sequence, including 39 major DRMs. CONCLUSION : The TaqPath Kit demonstrated higher genotyping performance compared to the ViroSeq assays. The TaqPath Kit was able to detect DRMs in the PR, RT and INI regions of various HIV-1 subtypes, offering a critical tool to identify and monitor HIV drug resistance to new and existing antiretroviral drugs targeting these regions.
Caregiver beliefs about childhood development and schooling outcomes : a qualitative study in Mahikeng, South Africa
(Wiley, 2025-03) Palmer, Tom; Jaoude, Gerard Abou; Granados, Rolando Leiva; Batura, Neha; Booysen, Frederik; Ebersohn, L. (Liesel); Gram, Lu; Prost, Audrey; Salustri, Francesco; Skordis, Jolene
Although the role of the home in supporting early childhood development, early learning and school outcomes is well established, the perspectives of caregivers on child development and schooling outcomes are comparatively underexplored. This qualitative study was conducted with caregivers of children aged 6–10 years in Mahikeng, South Africa and aimed to explore their beliefs related to the interconnected developmental continuum of ECD, school readiness and educational outcomes. A total of 18 caregivers participated in focus group discussions, including 2 males and 16 females. Qualitative data were analysed using reflexive thematic analysis. We developed four themes: being present; guiding children through school; influencing language and cognitive development and raising the next generation. Caregivers expressed beliefs that they played an important role in early language and cognitive development and in socioemotional development for older children. However, their behaviour was not necessarily motivated explicitly by child outcomes. Additionally, caregivers described many contextual factors, such as high levels of unemployment and crime, that may constrain the ability of households to support child development. Design of effective caregiving interventions must be informed by contextual understanding and help to overcome these barriers.
Migration narratives in the book of Genesis and Japa syndrome among Nigerian youths
(AOSIS, 2025-03) Chukwuma, Onyekachi G.; u05141517@tuks.co.za
The book of Genesis has copious narratives on migration. This article studies the migration stories of Abram’s and Jacob’s families vis-à-vis migration among Nigerian youths. A study of these biblical narratives reveals that severe famine precipitated the movement of these patriarchs and their families. Abram’s and Sarai’s migration to Egypt, according to Genesis 12:10, was a result of famine. Genesis 46 and 47 record that Jacob’s family migrated to Egypt due to the severe famine in Canaan. Similarly, many Nigerian youths migrate to other countries such as Canada, the United Kingdom, South Africa, Australia, Austria, Ireland, Germany, et cetera to escape financial hardship and pursue greener pastures. To this end, the slang ‘Japa’ has become a household term among Nigerian youths. Japa is a new word for leaving one’s country for better living conditions. With narrative and descriptive analysis, this article studies relevant texts in Genesis and the Japa phenomenon among Nigerian youths. A comparative study reveals that bad living conditions are hugely associated with migration in the Old Testament and contemporary times. The high rate of unemployment, underemployment, and a lack of opportunities faced by Nigerian youths are hugely responsible for the mass migration. The study recommends that the Nigerian government create an enabling environment that promotes the financial stability of youths through better job opportunities and career growth. CONTRIBUTION : Migration is a long-standing human activity that is generally attributed to the quest for better living conditions. In the Old Testament, famine was hugely responsible for movement from one biblical residence to another. Nigerian society has witnessed a mass migration of its youths to other countries to escape the present economic situation in the country. A comparative study shows that many people migrate because of uncomfortable situations in their residence locations; there are challenges associated with migration, and migration usually leads to improved living conditions.
IMA GENOME-F20 a draft genome assembly of Agroathelia rolfsii, Ceratobasidium papillatum, Pyrenopeziza brassicae, Neopestalotiopsis macadamiae, Sphaerellopsis filum and genomic resources for Colletotrichum spaethianum and Colletotrichum fructicola
(Pensoft Publishers, 2025-02) D’Angelo, Davide; Sorrentino, Roberto; Nkomo, Tiphany; Zhou, Xianzhi; Vaghefi, Niloofar; Sonnekus, Byron; Bose, Tanay; Cerrato, Domenico; Cozzolino, Loredana; Creux, Nicky; D'Agostino, Nunzio; Fourie, Gerda; Fusco, Giovanna; Hammerbacher, Almuth; Idnurm, Alexander; Kiss, Levente; Hu, Yanping; Hu, Hongli; Lahoz, Ernesto; Risteski, Jason; Steenkamp, Emma Theodora; Viscardi, Maurizio; Van der Nest, Magrieta Aletta; Wu, Yuan; Yu, Hao; Zhou, Jianjin; Dewage, Chinthani S. Karandeni; Kotta-Loizou, Loly I.; Stotz, Henrik U.; Fitt, Bruce D.L.; Huang, Yong-Ju; Wingfield, Brenda D.; brenda.wingfield@up.ac.za
Xpert MTB/XDR implementation in South Africa : cost outcomes of centralised vs. decentralised approaches
(International Union Against Tuberculosis and Lung Disease, 2024-05-01) Cassim, N.; Omar, Shaheed Vally; Masuku, S.D.; Moultrie, H.; Stevens, W.S.; Ismail, Farzana; Da Silva, P.
INTRODUCTION : In South Africa, Xpert® MTB/RIF Ultra (Ultra) is the recommended diagnostic assay for TB with line-probe assays for first- (LPAfl) and second-line drugs (LPAsl) providing additional drug susceptibility testing (DST) for samples that were rifampicin-resistant (RR-TB). To guide implementation of the recently launched Xpert® MTB/XDR (MTB/XDR) assay, a cost-outcomes analysis was conducted comparing total costs for genotypic DST (gDST) for persons diagnosed with RR-TB considering three strategies: replacing LPAfl/LPAsl (centralised level) with MTB/XDR vs. Ultra reflex testing (decentralised level). Further, DST was performed using residual specimen following RR-TB diagnosis. METHODS : The total cost of gDST was determined for three strategies, considering loss to follow-up (LTFU), unsuccessful test rates, and specimen volume. RESULTS : For 2019, 9,415 persons were diagnosed with RR-TB. A 35% LTFU rate between RR-TB diagnosis and LPAfl/LPAsl-DST was estimated. Unsuccessful test rates of 37% and 23.3% were reported for LPAfl and LPAsl, respectively. The estimated total costs were $191,472 for the conventional strategy, $122,352 for the centralised strategy, and $126,838 for the decentralised strategy. However, it was found that sufficient residual volume for reflex MTB/XDR testing is a limiting factor at the decentralised level. CONCLUSION : Centralising the implementation of XDR testing, as compared to LPAfl/LPAsl, leads to significant cost savings.
Impact of US funding cuts and stop work orders on TB services and research in South Africa
(International Union Against Tuberculosis and Lung Disease, 2025-04-09) Ndjeka, N.; Kubjane, M.; Abdullah, Fareed; Mohr-Holland, E.; Subrayen, P.; Loveday, M.; Dube, M.; Boffa, Jody
No abstract available.
Inequities underlie the alarming resurgence of Tuberculosis as the world's top cause of death from an infectious disease - breaking the silence and addressing the underlying root causes
(Elsevier, 2025-03) Zumla, Alimuddin; Sahu, Suvanand; Ditiu, Lucica; Singh, Urvasha; Park, Young-Joon; Yeboah-Manu, Dorothy; Osei-Wusu, Stephen; Asogun, Danny; Nyasulu, Peter; Tembo, Africa John; Kapata, Nathan; Tembo, John; Alyaqoubi, Fatma; Al Maani, Amal; Blumberg, Lucille Hellen; Zumla, Adam; Ahmed, Rizwan; Go, Unyeong; Hui, David; Goletti, Delia; Petersen, Eskild
No abstract available.

Browse

Recent Submissions